Best Aesthetics & Skin Clinic, London 2026

Skin

Cosmelan

A leading depigmentation programme for melasma, sun spots and stubborn dark patches. It fades pigment and helps stop it coming back.

Cosmelan depigmentation treatment

At a glance

In clinic

One mask session

At home

Skincare programme for up to 6 months

Skin types

Suitable for all

Downtime

Redness and peeling for a few days

Check-ins

Regular in-clinic reviews

Best for

Melasma, sun spots, post-inflammatory marks

Two phases, lasting results

Phase 1, in clinic. A professional-strength mask is applied and left on for a set number of hours, depending on your skin. You remove it at home.

Phase 2, at home. A personalised routine with azelaic acid, kojic acid, arbutin and phytic acid regulates melanin production for up to 6 months. We see you regularly to track progress and adjust the plan.

The programme

Why Cosmelan®

A world-leading depigmentation programme, trusted for stubborn pigmentation.

Over a million patients

Used by more than one million patients around the world.

Proven results

Excellent clinical results, backed by patented science.

All skin types

A non-invasive corrective treatment suitable for all skin types.

Lasting change

Reduces melanin production to even skin tone and help stop pigment returning.

In depth

Everything you need to know

How Cosmelan® works

Cosmelan® reduces the skin’s melanin production by blocking tyrosinase, the enzyme that drives pigment. It brightens and evens skin tone and helps prevent dark patches from coming back.

It treats hyperpigmentation including stubborn melasma, sunspots and marks left after acne or inflammation.

Phase 1: in clinic

Your programme starts with a professional-strength mask applied in clinic. It stays on for a set number of hours, depending on your skin type and pigmentation, and you remove it at home.

This phase starts the depigmentation process by gently resurfacing the skin and breaking down existing pigment.

Phase 2: at home

After the mask, you follow a personalised home programme for up to 6 months. It regulates ongoing melanin production and improves tone and texture with active ingredients including azelaic acid, kojic acid, arbutin and phytic acid.

We invite you back for regular skin analysis to check your progress, adjust your routine and guide you through each stage.

Getting the best results

Only Mesoestetic skincare should be used during the Cosmelan® method. This gives the best outcome and reduces the risk of reactions.

Daily high-factor sun protection is essential during and after the programme to keep pigmentation from returning.

Who it suits

Good to know

Questions we're often asked

It goes further than a peel. It removes pigment and also regulates its production, so dark areas are less likely to return.

The biggest change comes a few weeks after the mask. Keep going with the home phase to control the cause.

Pigment is likely to return, as production hasn’t been regulated yet.

Yes. It’s non-invasive, though some redness and peeling are normal at first.

Start with a consultation

Every treatment begins with a face-to-face assessment, so your plan is built around your skin, your health and your goals.